Bio materials used for implantable and in vivo tissue engineering


1) Biomaterials used for implantables and in vivo tissue engineering

  1. How has our understand by biocompatibility changed later years? (5 pts, 1/2 page)
  2. List the general prerequisites for any biomaterial to be clinically useful. (5 pts, 1/2 page)
  3. For tissue engineering and the use of biomaterials in combination with cells – what types of material characteristics are important to consider and why? (10 pts, 1 page)

2) Drug delivery systems

Most drug targets are intracellular posing a problem since the lipid bilayer membranes of cells are largely impermeable.

  1. What are the cellular uptake mechanisms and what are the approximate particle sizes these routes of internalization can handle? (10pts, 1 page)
  2. What mechanisms may be responsible for disruption and release of content to cytosol from internalized micro- and nanosized drug delivery vehicles (10pts, 1 page)
  3. What classes of drug delivery vehicles are available for researchers, and what are their limitations and advantages? (20pts, 2-4 pages)

4) Theragnostics (15pts)

What are contrast agents for ultrasound made of? How can ultrasound aid in drug delivery?


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