Define internal and external validity and come up with threats to both when you have a study where you measure maximal oxygen uptake before and after a training program over 3 years in a group of obese, untrained subjects 13 years of age.
You are about to design a study where you would like to determine whether a high fat/low carbohydrate diet influence exercise capacity and vascular function.
Design the study and write a:
You are about to design a study where you compare the effect of two programs of endurance training upon maximal oxygen uptake; interval training (10×1 minutes) or a isocaloric program of moderate continuous exercise.
You are given the following information: A clinical relevant difference in maximal oxygen uptake between two groups is 3 ml/kg/min and standard deviation for measuring maximal oxygen uptake in your laboratory is 5 ml/kg/min. Use power of 0.90 and (a two-tailed) pvalue less than 0.1
How many subjects do you need in each group to detect a real difference in training response between the two programs?
We have got a new system (OxyNew) for measuring maximal oxygen uptake in the laboratory that is much easier to use than the old apparatus (Gold Standard). The following data for maximal oxygen uptake were collected (data are in mL/kg/min):
How would you evaluate the strength of relation and agreement between the results for the two systems? Plot this in figures and gives numbers and explain why one expression form may be better than the other.
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