Discuss central elements of the functional genomics/systems biology research process and how it is applied.
Give examples related to a biological or biomedical problem for each of the steps. 15p
(-omics) was used? How were the results analysed and interpreted? 10p
In your research project, you are studying a protein known to be embedded in the lysosomal membrane, and that is phosphorylated at a yet uncharacterised amino acid residue.
Genetic testing for several traits and diseases are now offered directly to consumer via the internet, and can therefore be done relatively easily. Identify and discuss challenges and benefits that an increasing focus on genetic testing can have on individuals and on society.
A set of transcription factor binding sites can be represented with a sequence logo, similar to the one shown below. Describe the individual steps that are needed to make this type of logo. No formulas are needed.
X-ray crystallography can give you the three-dimensional structure of a protein molecule. Describe how this can help you to predict function of novel proteins, understand the mechanism of enzymes and receptors, and design or modify inhibitors.
Discuss why the mouse is an attractive model for a functional genomics approach to human biology.
Fluorescent proteins are used in confocal microscopy to study intracellular trafficking patterns of the proteins of interest.
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