This is a literature review that examines the relation of frailty to Osteoporosis, depression and social isolation in frailty patients. In this review, qualitative approach was used in finding common literature in a partial sampling of the related literature that dealt with research objectives. Literatures on Osteoporosis, depression and social isolation in relation to frailty condition, frailty were systematically reviewed. In addition, the relevant model and theory in this study was also examined. Most of the literature used in this study was accessed from peer-reviewed journals such as Academic Search Premier, JSTOR, Business Source Premier and Medline. These were identified from 2004 to 2013 and the reference list was pearled. The researcher extracted descriptive information on study populations, frailty research criteria, and outcomes from the selected papers, and quality rankings were assigned. Of the 1500 articles retrieved from the searches and 10 articles retrieved from the pearling, 10 of them met study inclusion criteria. In the 10 articles, the link between Osteoporosis, depression and social isolation to frailty were used to find out how the components are related with each other. The prevalence of frailty ranged from 5% to 58%.

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