Inhibitors of 17β-hydroxysteroid dehydrogenase type 3 in the treatment of prostate cancer

Inhibitors of 17ОІ-hydroxysteroid dehydrogenase type 3 in the treatment of prostate cancer Abstract 17 Гџ-hydroxysteroid dehydrogenase (17Гџ-HSD) type 3 is an enzyme found in high amounts in the testes and plays a major role in biosynthesis of androgens such as testosterone hormone which is responsible for both internal and physical male characteristics. The role of 17Гџ-HSD type 3 in Prostate cancer treatment has widely been studied with emphasis on the inhibitors of the enzyme. In normal cells, 17Гџ-HSD type 3 enzymes have binding sites on androgen receptors on to which they bind and enhance transcription of genes that facilitate their multiplication. In cancer, the activity of 17Гџ-HSD type 3 has been observed to be much higher as compared to normal cells and gene transcription for the enzyme occurs in 15 minutes or less. Various studies show that inhibitors do exist that compete for the 17Гџ-HSD type 3 binding sites on the androgen receptors and others that block the enzymes from binding onto the androgen receptors, these have been broadly divided into two groups namely steroidal and non-steroidal inhibitors. B

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