List the major leukocytes and their primary functions

 

1                     Examination question 1

  1. List the major leukocytes and their primary functions
  2. Briefly describe the physical /chemical barriers of host defense

Examination question 2

  1. Define monoclonal and polyclonal antibodies
  2. What are the advantages and the disadvantages with monoclonal and polyclonal antibodies when used as immunological tools?
  3. Draw and explain the principle of Enzyme-Linked ImmunoSorbent Assay (ELISA). Give an example on how it can be used in the clinics.

Examination question 3

  1. What molecules are presented on MHCI, MHCII and CD1, respectively? Which cells express these surface receptors?
  2. Draw a schematic and briefly explain the process of antigen presentation on MHCI and MCHII.
  3. What is cross-priming?
  4. Explain briefly how naïve T-cells are activated by dendritic cells?
  5. List T-cell subsets with characteristic receptors (to discriminate/identify them), main function and cytokine(s) secreted

Examination question 4

  1. List the (seven) hallmarks of cancer
  2. Briefly describe a proto-oncogene and a tumour suppressor gene
  3. What are the differences between tumour specific and tumour associated antigens?

Examination question 5

  1. Describe shortly how and where B-cells are activated by thymus-dependent antigens and progress to effector cells.
  2. Describe the cellular process of apoptosis; why it is important, molecular mechanism of one chosen pathway, and how apoptotic debris is removed

2

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