Oral Antihyperglycemic Therapy for Type 2 Diabetes. Scientific Review and Clinical Applications. Vol 287, No. 3, Retrieved from www.jama.ama-assn.org Abstract Background Diabetes mellitus affects more than 6% of the US population, with the great majority having type 2 diabetes mellitus (DM). In some older groups, the prevalence of DM and its metabolic forerunner, impaired glucose tolerance (IGT) approaches 25%. Throughout the past decade, a 30% increase in the prevalence of DM has been recorded in the United States, with the most dramatic increases in younger individuals. When the long-term complications of this disease and their costs are considered, the implications of these statistics are sobering. Methods A MEDLINE search was performed to identify all English-language articles of unique, randomized controlled clinical trials involving recently available oral agents for type 2 DM
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