Parkinson’s Disease

Parkinson’s disease is a degenerative disorder of the neurons. It is commonly seen in geriatrics aged 60 and above. More common forms of Parkinson’s disease are idiopathic, with only rare cases related to familial forms (Matsuda et al. 211). There is yet a known cause for Parkinson’s disease and researches are still ongoing to learn more about the disease. In fact, previous studies have found that formed aggregates of О±-synuclein cause the loss of dopaminergic neurons in an area of the brain called the substantia nigra (Winner et al. 4194). The loss of such neurons was found to result to the familiar symptoms of Parkinson’s disease, which are bradykinesia, tremors and postural instability (Mizuno et al. 22215). However, recent studies have identified certain genes to be crucial factors in the pathogenesis of this neurodegenerative disorder (Matsuda et al. 211). These genes have been identified as PINK1 (PTEN-induced putative kinase 1) and Parkin(Matsuda et al. 211; Deng et al. 14503).

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