Tissue engineering

 

 

 

1) Tissue engineering

  1. Briefly describe how extracellular matrix (ECM) is organized and why it would be beneficial to recreate ECM in respect to tissue engineering? (10pts,

1page)

  1. Describe three different techniques available for generating porous networks for tissue scaffold? (10pts, 1page)

2) Drug delivery

  1. For what reasons do we need drug delivery systems? (5pts, ½ page)
  2. What are the cellular mechanisms responsible for uptake of micro/nanoparticles by cells? (20pts, 2pages)
  3. What are the reasons for introducing polyethylene glycol (PEG) on the surface of drug delivery systems? (5pts, 1/2 page)
  4. Receptor-mediated cancer targeting has failed miserably in clinical settings. Why is cancer targeting so difficult? (5pts, 1/2pages)

3) Nanotoxicology

  1. What are the three hallmark processes of cellular toxicity? (5pts, 1/2page)
  2. Phagocytic cells can eat substrates bigger than themselves. What are the biochemical/cell biological consequences of non-degradable particles in tissues? (15pts, 2pages)

The semester paper is 25pts=100total.

Thank you.

2

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