What are the principal components of viruses?


In brief, explicate the following terms (use approx. 3-5 keywords and give relevant examples):

  1. Viral glycoproteins
  2. Latency
  3. Retrovirus
  4. Vaccine
  5. Interferon – Production and function

Examination question 2 (30 points)

  1. What are the principal components of viruses?
  2. What are the functions of the viral structural proteins?
  3. Briefly describe the basic steps in the viral life cycle
  4. Herpes- and adenoviruses are both viruses with linear double stranded DNAgenomes, but their replication mechanisms differ considerably. Give step by stepsummaries of both mechanisms (you may use drawings). Note: the question refers to replication mechanism and not life cycle.

Examination question 3 (20 points)

  1. Mention some cell surface molecules used by animal viruses as receptors. What is antibody-dependent enhancement of infectivity?
  2. Describe the steps from extracellular viral particle to intracellular genome for an animal virus. Highlight the difference in entry between enveloped and non-enveloped viruses.
  3. Describe in detail the fusion entry of the genome of an HIV-1 virion into a target cell. How does the drug Enfuvirtide (T-20) inhibit this process?


Examination question 4 (30 points)

  1. What determines the symptoms of viral infectious disease? Use examples from human medicine.
  2. Briefly explain the differences between acute and persistent viral infections on a clinical and molecular level. Use examples.
  3. What is meant by cell “tropism”? Which properties/aspects define the tropism of a virus?
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