What is a nuclear receptor? Describe its domain structure and outline its general mechanism of action. Provide three examples of nuclear receptors.


Question 1  )

What is a nuclear receptor? Describe its domain structure and outline its general mechanism of action. Provide three examples of nuclear receptors.

Question 2 

Describe a mechanism that explains how intracellular cAMP levels can be controlled by receptor signalling.

Question 3 (7 points)

Describe mechanisms that contribute to innate immunity against

  1. Extracellular pathogen-associated molecular patterns (PAMPs)
  2. Cytosolic PAMPs

Question 4  

  • (2 p.) Describe how activation of a receptor tyrosine kinase may cause activation of class I PI 3-kinase.
  • (3 p.) Describe the mechanism by which class I PI 3-kinase controls cell growth.

Question 4 

Describe how growth factor receptors are downregulated by endocytosis and lysosomal degradation.

Question 5 

  • (2 p.) Provide three examples of neurotransmitters and describe the two main types of neurotransmitter receptors.
  • (4 p.) Which roles do the following molecules play in synaptic functions?

a Dynamin b Voltage-gated Ca2+ channels c SNARE proteins

d Synaptotagmin

Question 7 

What is a stem cell? Describe two signalling pathways that contribute to expansion of the stem cell population. Which roles do the proteasomes play in these signalling pathways?

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